Epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer, suggests a new study published this week in iPLOS Medicine/i. HAND2 is active in the healthy endometrium (the tissue lining the uterus) where it antagonizes the growth-inducing effects of estrogen. By contrast, in more than 90% of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.
Martin ...
Epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer, suggests a new study published this week in iPLOS Medicine/i. HAND2 is active in the healthy endometrium (the tissue lining the uterus) where it antagonizes the growth-inducing effects of estrogen. By contrast, in more than 90% of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.
Martin ...